Laboratory Analyses
Expert Analysis, Reliable Results
Reliable results are obtained through scientific methods. With our expert team and advanced infrastructure, we provide comprehensive laboratory analysis services for cosmetics, food, pharmaceuticals, and chemical products.
“OECD Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method,” “OECD Test No. 491: Short Time In Vitro Assay for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage,” and “OECD Test No. 492: Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage” are performed on reconstructed human epidermal and corneal tissues by European Registered Toxicologists (ERTs) certified by MatTek Company.
“OECD Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method,” “OECD Test No. 491: Short Time In Vitro Assay for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage,” and “OECD Test No. 492: Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage” are performed on reconstructed human epidermal and corneal tissues by European Registered Toxicologists (ERTs) certified by MatTek Company.
Cytotoxicity tests are conducted in accordance with the **OECD Test No. 129: Guidance Document on the Use of Cytotoxicity Tests for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests**. However, if companies require alternative cytotoxicity test methods, these can also be implemented by **European Registered Toxicologists (ERTs)**.
All inflammatory and anti-inflammatory parameters can be measured using spectrophotometric/spectrofluorometric methods according to requirements. The measurements are carried out by European Registered Toxicologists (ERTs).
All inflammatory and anti-inflammatory parameters can be measured using spectrophotometric/spectrofluorometric methods according to requirements. The measurements are carried out by European Registered Toxicologists (ERTs).
Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is an elemental analysis technology capable of detecting most elements from the periodic table at concentrations ranging from milligrams to nanograms per liter. Atomic Absorption Spectroscopy (AAS) detects elements in liquid or solid samples by applying characteristic wavelengths of electromagnetic radiation from a light source. Individual elements absorb wavelengths differently, and this absorbance is measured against standards. All heavy metals, metals, and essential element levels can be measured using ICP-MS or Atomic Absorption Spectroscopy (AAS) according to requirements. Measurements are performed by European Registered Toxicologists (ERTs).
Phototoxicity is a condition in which the skin or eyes become highly sensitive to sunlight or other forms of light. It can result from the application of certain drugs, some essential oils, or other topical agents to the skin. The “OECD Test No. 432: In Vitro 3T3 NRU Phototoxicity Test” is conducted by European Registered Toxicologists (ERTs) for pharmaceuticals, cosmetics, and personal care products. The tests are performed by European Registered Toxicologists (ERTs).
Abnormal toxicity test is an in vivo method conducted as a form of quality control to detect any potentially hazardous biological contamination before direct application in humans is approved. Although it is not mandatory for drugs by regulatory authorities in some countries, it is still required in some countries for vaccines and vaccine components.
Biocompatibility is the most commonly used term to define the appropriate biological requirements of a biomaterial or biomaterials used in a medical device. It has also been described as the ability of a material to perform with an appropriate host response in a specific application. The biological evaluation of medical devices according to ISO 10993 is conducted by European Registered Toxicologists (ERTs).
“OECD Test No. 420: Acute Oral Toxicity – Fixed Dose Procedure,” “OECD Test No. 423: Acute Oral Toxicity – Acute Toxic Class Method,” and “OECD Test No. 425: Acute Oral Toxicity – Up and Down Procedure” tests are performed to predict the acute toxicity of drugs, drug ingredients, certain chemicals, vaccines, and vaccine ingredients. These tests are conducted by European Registered Toxicologists (ERTs)."
“OECD Test No. 407: Repeated Dose 28-Day Oral Toxicity Study in Rodents,” “OECD Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents,” and “OECD Test No. 452: Chronic Toxicity Studies” are conducted to assess the toxicity of drugs, drug components, certain chemicals, vaccines, and vaccine ingredients. Tests are performed by European Registered Toxicologists (ERTs). Additional subacute, subchronic, or chronic toxicity tests can also be performed based on company requests.
For medical devices, “ISO 10993-10:2021 Biological Evaluation of Medical Devices — Part 10: Tests for Irritation and Skin Sensitization” is conducted by European Registered Toxicologists (ERTs).
For medical devices, “ISO 10993-10:2021 Biological Evaluation of Medical Devices — Part 10: Tests for Irritation and Skin Sensitization” is conducted by European Registered Toxicologists (ERTs).
For medical devices, “ISO 10993-10:2021 Biological Evaluation of Medical Devices — Part 10: Tests for Irritation and Skin Sensitization” is conducted by European Registered Toxicologists (ERTs).
For medical devices, “ISO 10993-10:2021 Biological Evaluation of Medical Devices — Part 10: Tests for Irritation and Skin Sensitization” is conducted by European Registered Toxicologists (ERTs).
Particle size and size distribution are measured by European Registered Toxicologists (ERTs) using ZetaSizer. Comparisons and statistical analyses of particle size between original drugs and generic drugs are also performed.
Aflatoxins and Zearalenone in biological fluids, food, feed, breast milk, infant formulas, and other samples are measured by European Registered Toxicologists (ERTs) using high-performance liquid chromatography (HPLC).
Aflatoxins and Zearalenone in biological fluids, food, feed, breast milk, infant formulas, and other samples are measured by European Registered Toxicologists (ERTs) using high-performance liquid chromatography (HPLC).
Aflatoxins and Zearalenone in biological fluids, food, feed, breast milk, infant formulas, and other samples are measured by European Registered Toxicologists (ERTs) using high-performance liquid chromatography (HPLC).
Aflatoxins and Zearalenone in biological fluids, food, feed, breast milk, infant formulas, and other samples are measured by European Registered Toxicologists (ERTs) using high-performance liquid chromatography (HPLC).
The Comet assay (single-cell gel electrophoresis) is a simple method used to measure DNA strand breaks in eukaryotic cells. Cells embedded in agarose on a microscope slide are lysed with detergent and high salt to form nucleoids containing supercoiled DNA loops attached to the nuclear matrix. “OECD Test No. 489: In Vivo Mammalian Alkaline Comet Assay” is conducted by European Registered Toxicologists (ERTs) to detect DNA damage induced by drugs, cosmetics, personal care products, or vaccines. Additionally, depending on company requirements, double-strand breaks (DSBs) can be detected using the neutral Comet assay.
DNA base damage, single-strand breaks (SSBs), double-strand breaks (DSBs), or other DNA damage parameters caused by drugs, cosmetics, personal care products, or vaccines can be measured spectrophotometrically by European Registered Toxicologists (ERTs).
“TS and ISO 10993-10:2010 Skin Irritation and Skin Sensitization Test for Medical Devices” is performed by European Registered Toxicologists (ERTs).
The Ames test is a widely used method that utilizes bacteria to determine whether a specific chemical causes mutations in the DNA of the test organism. More specifically, it is a biological method for assessing the mutagenic potential of chemical compounds. “OECD Test No. 471: Bacterial Reverse Mutation Test” is conducted by European Registered Toxicologists (ERTs).
The combined use of bacterial gene mutation tests and chromosomal aberration tests in mammalian cells may fail to detect a small proportion of mammal-specific mutagenic agents. Therefore, currently, a third assay should be employed except for compounds with very low or no exposure (DOH (2000) Health Guide for Testing Chemicals for Mutagenicity. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment). The hypoxanthine phosphoribosyltransferase (HPRT) gene is located on the X chromosome of mammalian cells and is used as a model gene to investigate gene mutations in mammalian cell lines. This test can detect a wide variety of chemicals that may cause DNA damage leading to gene mutations.
Test, timidin kinaz (TK) fare lenfoma tahliline (MLA) çok benzer bir metodoloji izler ve her ikisi de OECD (1997) memeli gen mutasyon testleri kılavuzlarına dahil edilmiştir (Kimyasalların Test Edilmesine İlişkin OECD Yönergelerine dokuzuncu ek. In Vitro Memeli Hücre Gen Mutasyon Testi: 476). HPRT testi, Avrupa Kayıtlı Toksikologlar (ERT’ler) tarafından gerçekleştirilir.